Abstract
The synthesis and structure-activity relationship studies of 1,4,5,6-tetrahydropyridazines are described. The target compounds 3-5 represent a novel class of potent and selective CB1 receptor antagonists.
MeSH terms
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Animals
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CHO Cells
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Cricetinae
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Cricetulus
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Humans
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Pyridazines / chemical synthesis*
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Pyridazines / chemistry
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Pyridazines / pharmacology
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Receptor, Cannabinoid, CB1 / antagonists & inhibitors*
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Receptor, Cannabinoid, CB1 / metabolism
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Structure-Activity Relationship
Substances
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Pyridazines
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Receptor, Cannabinoid, CB1